The Gunners travel to Selhurst Park in the midweek, where Arsenal have been relatively unsuccessful over the years.
There is little for Arsenal to play for there, except pride and a potential spot in the European Conference League if they are able to finish in seventh.
Mikel Arteta has a range of players to choose from, including youth. Here are the youngsters who the Spaniard could start.
Omar Rekik
Arsenal have a plethora of centre backs at their disposal, and Rekik joined this list in January.
The 19-year-old came from Hertha Berlin for a small fee, but has barely had time to shine this season due to injury problems.
This penultimate match against Crystal Palace may give Rekik a chance to show the fans what he is made of.
Folarin Balogun
Balogun has already made his debut for Arsenal, but is yet to make a Premier League one. He quickly became a fan-favourite with his performances in the Europa League, however there was stage of uncertainty as to whether he would stay at the Emirates.
Nonetheless Balogun has committed his future to the club and Arteta may be in line to reward him with his Premier League debut.
The 19-year-old has already been tipped for greatness by many and this would give him a chance to prove his worth.
Arthur Okonkwo
Okonkwo has been training with the first-team squad for a while now, however is also yet to make a start.
The goalkeeper has previously made the bench for the Gunners though.
The 19-year-old faces competition from Maty Ryan and Rúnar Alex Rúnarsson for the spot though, who will all be wanting to gain minutes.