Blackpool head into the game in great form, with four wins from their last five games helping them into sixth position.
Neil Critchley's men earned a well-fought 1-0 win at Sheffield United on the weekend, with Keshi Anderson scoring the winner.
Stoke City are the polar opposite to their opponents, with one draw and four losses in their previous five undoing their good start and leaving them in ninth place.
They let a three-goal lead slip to eventually draw 3-3 against Cardiff City at home last time out.
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Team news
Kenny Dougall is likely to be available, after picking up a knock at the weekend.
Kevin Stewart may return to the squad, but faces a late fitness test to be fit for the visit of the Potters.
Chris Maxwell (torn quad), Matty Virtue (ACL), Grant Ward (achilles) and Shayne Lavery (hamstring) all remain sidelined.
Daniel Gretarsson (concussion), Reece James and CJ Hamilton (both foot) are now back in training.
Brighton & Hove Albion loanee Abdallah Sima has a groin problem, and will miss the trip to the Fylde coast.
Morgan Fox (hamstring) has returned to training but is not likely to be involved in the matchday squad as of yet.
Nick Powell (leg), Sam Clucas (quad) and Alfie Doughty (hip) remain sidelined for the Potters.
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Predicted lineups
Blackpool (4-4-2)
Grimshaw; Gabriel, Keogh, Ekpiteta, Husband; Bowler, Dougall, Wintle, Anderson; Yates, Madine.
Stoke City (3-5-2)
Bursik; Wilmot, Souttar, Batth; Smith, Allen, Sawyers, Thompson, Tymon; Brown, Fletcher.
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Ones to watch
No doubt one of Neil Critchley's most important players, Doncaster-born Yates scored 20 goals in 44 league games last season as he fired the Seasiders back into the Championship, with the joint highest scored in a single campaign by a Blackpool player since Andy Watson in 1993–94.
The 24-year-old striker was voted the the PFA Fans' Player of the Year for the 2020–21 League One campaign and has again showed signs of his attacking prowess this time around, with five goals in 14 Championship games. Stoke's leaky backline will need to be alert to stop Yates, who has scored four in his last five games.
Jacob Brown
23-year-old Brown has started this season in a rich vein of form, with four goals and four assists from the opening 15 Championship games. He has been deployed in a striker role, rather than as a winger, and his game has benefitted massively from that change.
Brown began his career at Barnsley and moved to the Potters in 2020, initially coming under scrutiny for his poor form in front of goal. He has managed to prove many of his doubters wrong this time around, with Steve Clarke rewarding him with a call-up to the Scottish national team this week.
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Previous meetings
The last game between these two was last season, with Stoke progressing in the first round of the League Cup after winning 5-4 on penalties after a 0-0 draw in normal time.
The previous game between the two before that was also a 0-0 draw at Bloomfield Road in 2011, with the earlier fixture ending 1-0 to Blackpool.
In 72 meetings overall, Stoke have won 30 games, with 20 draws and 22 Tangerines victories.
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How to watch
The game kicks off at 19:45 GMT on Wednesday November 3.
It will be available to watch on Sky Sports Red Button.