Leeds United visit the London Stadium for the second time in seven days as they square off with West Ham United.
The Hammers ran out winners in the third-round FA Cup tie and followed that up with a victory over Norwich City that saw them reclaim fourth place in the Premier League table.
Leeds are 16th, but their most recent league fixture was a critical 3-1 win over Burnley which has them five points clear of the relegation zone.
Team news
West Ham United
The Hammers are hopeful that midfielder Tomas Soucek can return after a bout with COVID-19 forced him to miss the win over Norwich.
Defender Kurt Zouma returned to training ahead of a schedule following a hamstring injury and he faces a late fitness test.
Angelo Ogbanna has been ruled out with a knee issue while Mark Noble and Ryan Fredericks both sat out in midweek.
Leeds United
Patrick Bamford has been battling ankle hip injuries, but the Whites are hopeful he can play a part in this contest.
Rodrigo (heel) and Pascal Struijk (foot) have both been out since November, but they could feature here.
Tyler Roberts is out through suspension, Diego Llorente is nursing a calf injury and Kalvin Phillips and Liam Cooper are both sidelined with hamstring issues.
Predicted line-ups
West Ham United: Fabianski; Cresswell, Diop, Dawson, Coufal; Masuaku, Lanzini, Rice, Fornals, Bowen; Antonio
Leeds United: Meslier; Firpo, Struijk, Koch, Ayling; Dallas, Forshaw; Harrison, Klich, Raphinha; Bamford
Ones to watch
Jarrod Bowen (West Ham United)
The pacy forward has been the Hammers best player. scoring eight goals and assisting on eight others while consistently putting in solid performances.
The £22m paid to Hull City looks to be a bargain for a player that will be in the England international squad sooner rather than later.
Raphinha (Leeds United)
Subject of much transfer talk due to his outstanding play, the Whites will be keen to hold onto the Brazilian, especially in the face of the club continuing to play with a shorthanded side.
Previous meeting
The two sides met just last week in the third round of the FA Cup with West Ham emerging 2-0 winners.
West Ham went in front in the 34th minute when Nikola Vlasic turned smartly in the box only to be denied by Ilian Meslier with Manuel Lanzini on hand to fire home the rebound.
Leeds were unhappy as they felt Bowen was offside in the build-up, but the goal was upheld after a lengthy VAR check.
Bowen and Fredericks both then went close to doubling the Hammers advantage before the former Hull man sealed the match on the counter in the third minute of injury time.
How to watch
The match will be broadcast live in the UK by Sky Sports Main Event, Sky Sports Premier League and Sky Sports Ultra HD.
Kick-off is set for 2pm UK time.