21 places and 28 points seperate the two sides ahead of kick-off, with Huddersfield Town looking to continue their unbeaten run, which currently sits at 17 games, at the expense of a side who have not won a league game so far this year.
For Huddersfield lies the chance of getting into the automatic promotion spot for the first time this season, albeit with current second place holders Bournemouth holding four games in hand above their heads.
For Peterborough United the chance to go top of the drop zone awaits, with a win tomorrow due to take them five points from safety, one point away from fellow relegation-fighters Barnsley, and three away from stricken Derby County.
Team news
Having shown flexibility with his approach of late, it would come as no surprise if Carlos Corberan recalls several Huddersfield players at the weekend.
Danny Ward is likely to get the nod ahead of Jordan Rhodes, while one of Josh Koroma or Daniel Sinani is in line to replace Duane Holmes.
Chelsea loanee Levi Colwill impressed on his first showing in almost two months against Birmingham City last time out, doing enough to retain his spot in defence, although Blues teammate Tino Anjorin is still fighting to feature after an ankle injury.
Despite the three-day turnaround, Grant McCann may be prepared to stick with the majority of the Peterborough players who started in a 2-0 loss to Man City.
However, Oliver Norburn is back from suspension, while Joe Taylor and Callum Morton come into contention after being cup-tied on Tuesday night.
Predicted lineups
Huddersfield: Nicholls (GK), Turton, Pearson, Colwill, Toffolo, Russell, Hogg, O'Brien, Thomas, Ward, Koroma
Peterborough: Benda (GK) Knight, Edwards, Kent; Ward, Fuchs, Norburn, Coulson, Szmodics, Morton, Marriott
Ones to watch
The on-loan Chelsea defender was enjoying a fantastic season with the Terriers before a nasty injury ruled him out for two months. After returning to the starting 11 against Birmingham with a goal and a fine performance, the centre back will be raring to go again.
It's fair to say that Clarke-Harris has not enjoyed the spoils of the Championship as much as he did League One last season, but a test against summit-nearing opposition is something for the striker to lick his lips at. Clarke-Harris scored the equaliser for United in their last game against Huddersfield in a 1-1 draw.
Previous meetings
The last time these two sides faced off was in a 1-1 draw at Peterborough at the start of November. Danny Ward had struck what looked to be the winner 15 minutes from time, before Jonson Clarke-Harris popped up to score an equaliser with just five minutes left on the clock.
How to watch
The game is on Friday March 3 and will kick off at 19:45 GMT. Coverage of the game is available from the Sky Sports app and on Sky Sports Red Button.