Preston North End have little to play for but pride as the season comes to an end, but league games come no bigger than this fierce rivalry between two clubs separated by just 17 miles.
Ryan Lowe's side have won just one of their last seven games, with their last outing a 1-0 loss away at Derby County after a late Ravel Morrison winner.
The Lilywhites are 15th in the Championship table with seven games to go, unlikely to trouble the play-off race and not threatened by the prospect of relegation.
Blackpool have enjoyed their return to the second tier so far, with Neil Critchley's side sitting comfortably in mid-table with eight games of their campaign left heading into this big clash.
The Tangerines' good run of three wins and a draw came crashing to an end at the weekend as they lost 4-1 to Nottingham Forest at Bloomfield Road in front of the Sky cameras.
They are 14th in the table, one point and one place ahead of their rivals with a game in hand.
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Team news
Preston North End
PNE will be without central defender Liam Lindsay for the match, after he picked up a red card against Derby for a professional foul.
Ched Evans, Greg Cunningham and Bambo Diaby are all back in contention after they missed the trip to Derbyshire at the weekend.
Ryan Ledson (knee), Tom Barkhuizen (calf) and Izzy Brown (achilles) are the only expected absentees for the hosts.
Dujon Sterling faces a late fitness test after going down with an ankle injury late on against Nottingham Forest last time out.
Jordan Gabriel has trained ahead of the game but is unlikely to feature from the start after five weeks out with a hamstring injury.
Luke Garbutt is nearing a return to action but this game comes too soon for him as he continues to build up match fitness following a knee injury.
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Predicted lineups
Preston North End (3-5-2)
Iversen; van den Berg, Bauer, Hughes; Potts, Browne, Whiteman, Johnson, Cunningham; Evans, Archer
Blackpool (4-4-2)
Grimshaw, Sterling, Ekpiteta, Keogh, Husband, Stewart, Dougall, Bowler, Anderson, Madine, Yates.
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Ones to watch
At just 20 years old, Archer has been a key component in North End's upturn in fortunes since the turn of the year, arriving on loan from Aston Villa in January following a prolific first half of the season in the EFL Cup and EFL Trophy with 10 goals in six games.
He was called up to the England Under 20 squad for the first time in November, and has netted five goals in 13 appearances since arriving at Deepdale. A quick striker with pinpoint finishing, Lowe and Preston fans alike will be hoping that Villa allow him to stay on for another season after this one comes to a close.
Bowler has enjoyed a breakthrough season in 2021/22, after joining Blackpool from Everton on a free transfer in the summer. The 22-year-old winger failed to make an impression at Hull City in the 2019/20 season, scoring just one goal in 31 games.
The winger has looked at home in the second tier since joining Neil Critchley's side, and his good form saw him touted for a move to Nottingham Forest or Bournemouth in January. A very tricky customer for full-backs, he has netted eight goals and picked up three assists in 41 games in this campaign. Preston's defence will have to be on high alert with him around on Tuesday evening.
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Previous meetings
The Seasiders ran out 2-0 winners in the reverse fixture in October after goals from Keshi Anderson and Gary Madine in the first West Lancashire derby in eight years.
Blackpool are looking to complete their first league double over Preston since 1973/74.
Preston have won just two of the last seven games between the teams at Deepdale, with three Blackpool wins and two draws.
The overall record between the teams is 46 Preston wins, 20 draws and 31 Blackpool victories in 97 games.
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How to watch
The game kicks off at 19:45 BST on Tuesday April 5.
It will be shown live on Sky Sports Main Event with coverage starting at 19:30.