Brentford return home to face London rivals Tottenham Hotspur at the Brentford Community Stadium.
The Bees picked up their third straight victory following Pontus Jonsson's stoppage-time winner against Watford to vault them to 12th in the Premier League table.
Tottenham were defeated by Brighton last time out, stopping a run of four consecutive wins. Spurs are battling Arsenal, Manchester United and West Ham United for a place in next season's Champions League.
Team news
Matthias Zanka has been ruled out for the remainder of the season with an adductor issue.
Ethan Pinnock and Sergi Canos are both absent due to hamstring injuries while Frank Onyeka is also out with an ankle issue.
Matt Doherty and Japhet Tanganga will miss the rest of the season with injuries.
Oliver Skipp remains sidelined with a groin injury with manager Antonio Conte reporting no other issues.
Predicted line-ups
Brentford: Raya; Henry, Sørensen, Jansson, Ajer; Eriksen, Nørgaard, Janelt; Wissa, Toney, Mbeumo
Tottenham Hotspur: Lloris; Davies, Dier, Romero; Sessegnon, Højbjerg, Bentancur, Royal; Son, Kane, Kulusevski
Ones to watch
Christian Eriksen (Brentford)
Just getting onto the pitch has made his return to action following his cardiac arrest for Denmark at last year's Euros successful, but his immense talent and ability to contribute, with a goal and two assists in his last four games, make this the story of the top-flight season.
The Bees have won all five games Eriksen has started, a statistic that should surprise no one.
Harry Kane (Tottenham Hotspur)
Always the focus of the opposing defense, Kane didn't score in the reverse fixture, making Brentford the only one of the 32 Premier League opponents he has faced he has not found the back of the net against.
He's been particularly effective in London derbies, registering 50 points, trailing only Thierry Henry in that category.
Previous meetings
In December, Tottenham defeated Brentford 2-0 to win back-to-back league matches under Antonio Conte for the first time.
Alvaro Fernandez denied Lucas Moura ten minutes in after the Brazilian was played in by Harry Kane.
Spurs did take the lead soon after as Heung-Min Son sent in a cross following a short corner that Jansson headed against Sergi Canos that flew into the net.
The South Korean could have extended the hosts' lead with a 20-yard shot if not for a spectacular save by Fernandez.
Tottenham did find a second off of a counter-attack. Kane played in Sergio Reguilon down the left-hand side and his ball across the face of goal was tapped in by Son.
How to watch
The match will be televised by Sky Sports Main Event with kick-off set for 5:30pm UK time.